Clin Hemorheol Microcirc. Neurochem.Res 2008;33(12):2444-2471. when applied to the skin for up to 30 days or when taken by mouth in doses up to 1500 mg daily for up to 3 months. naturals capsules resveratrol mg Soleas GJ, Diamandis EP, Goldberg DM. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., and Sinclair, D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. 
1-21-2000;66(9):769-777. View abstract. 
View abstract. Resveratrol: a molecule whose time has come? Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells. Steigerwald, M. D., Fisk, M. Z., Smoliga, J. M., and Rundell, K. W. Effects Of Resveratrol On Oxidative Stress And Vascular Function Following Exercise In Simulated Air Pollution: 2645. Antiviral Res 1999;43:145-55. Inflammation 2007;30:1-6. A., Merei, A., Halmai, R., Meszaros, L. G., Sumegi, B., and Wittmann, I. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Nature 9-11-2003;425(6954):191-196. 
View abstract. 2008;2(6):351-374. J Physiol Pharmacol. View abstract. It is also used for symptoms of a lung disorder "chronic obstructive pulmonary disease" and to improve the health of the liver in people with liver damage not caused by drinking alcohol. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. View abstract. View abstract. Howells, L. M., Berry, D. P., Elliott, P. J., Jacobson, E. W., Hoffmann, E., Hegarty, B., Brown, K., Steward, W. P., and Gescher, A. J. Jacobson JS, Troxel AB, Evans J, et al. View abstract. Olas, B., Wachowicz, B., Bald, E., and Glowacki, R. The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds. resveratrol bluebonnet 500mg antioxidant View abstract. View abstract. Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. View abstract. 
Resveratrol might slow blood clotting. View abstract. View abstract. Li W, Seifert M, Xu Y, Hock B. Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotillo, D., de Gaetano, G., Evangelista, V., and Cerletti, C. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. FASEB J 2003;17:2339-41. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. It is used as a medicine. resveratrol puritan Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. View abstract. View abstract. Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD. View abstract. 10-17-2003;278(42):41482-41490. Kirk, R. I., Deitch, J. Falchetti, R., Fuggetta, M. P., Lanzilli, G., Tricarico, M., and Ravagnan, G. Effects of resveratrol on human immune cell function. View abstract. J Med Food 2008;11(4):610-614. It may also decrease pain and swelling (inflammation). Lin, J. K. and Tsai, S. H. Chemoprevention of cancer and cardiovascular disease by resveratrol. Fabbrocini, G., Staibano, S., De, Rosa G., Battimiello, V., Fardella, N., Ilardi, G., La Rotonda, M. I., Longobardi, A., Mazzella, M., Siano, M., Pastore, F., De, Vita, V, Vecchione, M. L., and Ayala, F. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. resveratrol potent 500mg nutrica antioxidant Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. Cancer Res 11-15-2010;70(22):9003-9011. Ziegler CC, Rainwater L, Whelan J, McEntee MF. Baur, J. J.Gerontol.A Biol.Sci.Med.Sci. Antiviral Res. View abstract. Am J Cardiol. Guarnieri, R., Pappacoda, A., and Solitro, S. [A resveratrol containing compound reduces oxidative stress and ameliorates clinical symptoms in COPD subjects] Un composto a base di resveratrolo riduce lo stress ossidativo e migliora la sintomatologia clinica in soggetti con BPCO. Shock 2008;30(3):324-328. reserveage resveratrol Toxicology 8-7-2000;148(2-3):187-197. Beneficial effects of resveratrol on atherosclerosis. View abstract. View abstract. Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders. Davy BM, Melby CL, Beske SD, et al. A blueprint for developing therapeutic approaches that increase healthspan and delay death. Klabunde, T., Petrassi, H. M., Oza, V. B., Raman, P., Kelly, J. W., and Sacchettini, J. C. Rational design of potent human transthyretin amyloid disease inhibitors. View abstract. resveratrol reserveage caps mg cellulose vegetable capsule silica dicalcium stearate magnesium phosphate shell ingredients A., Perloff, M., Crowell, J. Circulation 9-24-2002;106(13):1652-1658. The following doses have been studied in scientific research: You are encouraged to report negative side effects of prescription drugs to the FDA. The Sciences and Engineering 2009;70(4-B). Pace-Asciak CR, Rounova O, Hahn SE, et al. View abstract. Br.J.Pharmacol. 2010;91(6):1590-1597. Kimura, Y., Okuda, H., and Kubo, M. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Scarlatti F, Sala G, Somenzi G, et al. Burkitt, M. J. and Duncan, J. Some medications changed by the liver include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin, and many others. 2009;29(8):1164-1171. Cell Metab. Resveratrol is POSSIBLY SAFE
Wuertz, K., Quero, L., Sekiguchi, M., Klawitter, M., Nerlich, A., Konno, S., Kikuchi, S., and Boos, N. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. View abstract. Clin Biochem 2003;36:79-87.. View abstract. Orallo, F. Trans-resveratrol: a magical elixir of eternal youth? Br.J.Cancer 3-4-2002;86(5):774-778. Biochem Biophys Res Commun 1999;254:739-43. 
View abstract.
Journal of Urology 2009;181(4). Lyons MM, Yu C, Toma RB, et al. Int.J Cardiol 11-2-2005;105(2):209-215. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Carcinogenesis 1999;20:237-42. J Gerontol.A Biol.Sci.Med Sci. Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. View abstract. Bertelli AA, Giovannini L, Giannessi D, et al. Hudson, G. M., Shelmadine, B., Cooke, M., Genovese, J., Greenwood, M., and Willoughby, D. S. Resveratrol Supplementation And Changes In Glucose, Insulin, And mRNA Expression Following Exercise In Overweight Females: 2467. 10-23-2012;8(5):790-793. Liu K, Zhou R, Wang B, Mi MT. Oncol Rep 2004;11:441-6. Biochem.Pharmacol. See additional information. Chirality 2004;16:190-5. Resveratrol might decrease how quickly the liver breaks down some medications. 2010;19(4):1359-1370. Cancer Res 2004;64:696-703. Patel, K. R., Brown, V. A., Jones, D. J., Britton, R. G., Hemingway, D., Miller, A. S., West, K. P., Booth, T. D., Perloff, M., Crowell, J. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Endocrinology 2000;141:3657-67. View abstract. 2014 Jun;99(6):1510-9. View abstract. View abstract. Stop using resveratrol at least 2 weeks before a scheduled surgery. View abstract. Shishodia S, Aggarwal BB. J Neuroophthalmol. Curr Med Res Opin.
Biochem.Mol.Biol.Int. J Nutr 2004;134:5-10. View abstract. J Pharmacol.Exp.Ther 2010;335(3):788-798. Xenobiotica 2000;30(11):1047-1054. Sharma, M. and Gupta, Y. K. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats.
View abstract. View abstract. 2004;32(12):1377-1382. A., De Jonge, R., Beemster, P., and De Jong, J. W. Does resveratrol induce pharmacological preconditioning? Bioorg Med Chem 2004;12:5571-8. Wang, M. J., Huang, H. M., Hsieh, S. J., Jeng, K. C., and Kuo, J. S. Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation. View abstract. J Am Soc Hortic Sci. View abstract. Resveratrol: a polyphenol for all seasons. Ann.Rheum.Dis 2012;71(1):129-135. Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. View abstract. Proc Natl Acad Sci U S A 1997;94:14138-43. Arch.Biochem.Biophys. Trincheri NF, Nicotra G, Follo C, et al. Resveratrol inhibits human squalene monooxygenase. Nature 8-5-2004;430(7000):686-689. View abstract. 2008;48(3):709-714. View abstract. A., and Tredici, G. Anti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis in the human neuroblastoma SH-SY5Y cell line. Int.J.Cancer 5-1-2003;104(5):587-596. Wang Q, Li H, Wang XW, et al. Drugs Exp Clin Res 1996;22:61-3. 2001;299(3):874-882. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. Resveratrol, a red wine constituent polyphenol, protects from ischemia-reperfusion damage of the ovaries. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding. View abstract. View abstract. View abstract. View abstract. Rakici, O., Kiziltepe, U., Coskun, B., Aslamaci, S., and Akar, F. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. Ann N Y.Acad Sci 2007;1100:530-542. View abstract. J Ethnopharmacol. View abstract. View abstract. Zhang Y, Jayaprakasam B, Seeram NP, et al. 2014 Oct;30(10):1931-5. Diabetes 2011;60(2):634-643. Int.J Tissue React. View abstract. Rapid Commun.Mass Spectrom. View abstract. Le Couteur, D. G. and Sinclair, D. A. 
Resveratrol-associated renal toxicity. 
View abstract. Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. View abstract. Pervaiz S. Resveratrol: from grapevines to mammalian biology. Subbaramaiah, K., Michaluart, P., Chung, W. J., Tanabe, T., Telang, N., and Dannenberg, A. J. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. View abstract. Am.J.Physiol Gastrointest.Liver Physiol 2002;282(5):G809-G816. Giovannini, L., Migliori, M., Longoni, B. M., Das, D. K., Bertelli, A. Pace-Asciak CR, Hahn S, Diamandis EP, et al. View abstract. 2000;51(3):513-520. Mndez-del Villar M, Gonzlez-Ortiz M, Martnez-Abundis E, Prez-Rubio KG, Lizrraga-Valdez R. Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. 4-13-2001;302(1):41-44. Dudley, J. I., Lekli, I., Mukherjee, S., Das, M., Bertelli, A. Kim YA, Choi BT, Lee YT, et al. A., Brenner, D. E., Steward, W. P., Gescher, A. J., and Brown, K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Some medications changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and otherslovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others. Vitamin D Deficiency: How Much Vitamin D Is Enough? Cancer Epidemiol Biomarkers Prev 2007;16:1246-52. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Life Sci. Clin Gastroenterol Hepatol. Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane). Mastromarino P, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L. Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia. J Alzheimers.Dis 2010;19(1):11-26. Chan, W. K. and Delucchi, A. 2004;55(2):467-476. View abstract. J.Biol.Chem. resveratrol lifeirl nutrica Bagchi, D., Bagchi, M., Stohs, S. J., Das, D. K., Ray, S. D., Kuszynski, C. A., Joshi, S. S., and Pruess, H. G. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. J Biol Chem 2004;279:22727-37. Curr.Med Chem. However, some early research shows conflicting results. Basly, J. P., Marre-Fournier, F., Le Bail, J. C., Habrioux, G., and Chulia, A. J. Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. resveratrol resvitale 500mg Journal of Hypertension 2010;28. 2004;24(5A):2783-2840. Biochem Pharmacol 2004;67:1399-410. Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Yanez-Gascon, M. J., Garcia-Almagro, F. J., Ruiz-Ros, J. View abstract. resveratrol highest 500mg Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. Mueller SO, Simon S, Chae K, et al. Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. 
Cancer Res. View abstract. Holmes-McNary M, Baldwin AS, Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Gruber, J., Tang, S. Y., and Halliwell, B. Ther.Adv.Respir.Dis.
View abstract. Biochem.Pharmacol.
Zou, J. G., Huang, Y. Yoon, S. J., Cho, K. S., Lee, Y. H., Kim, D. S., and Hong, S. J. RESVERATROL INHIBITS CXCR4 MEDIATED TUMOR GROWTH AND MIGRATION OF HUMAN KIDNEY CANCER CELL IN VITRO AND IN VIVO: 428. Clin Chim Acta 1995;235:207-19. Piver, B., Berthou, F., Dreano, Y., and Lucas, D. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. BMC Gastroenterol 2006;6:35. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. 
Drugs Exp Clin Res 1998;24:133-8. Boca Raton, FL: CRC Press, 2005. 8-1-2012;110(3):356-363. Effects of resveratrol in inflammatory arthritis. Visit the FDA MedWatch website or call 1-800-FDA-1088. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. Nutr.Metab Cardiovasc.Dis 2011;21(11):851-856. View abstract. 2009;29(8):1169-1180. Kozuki Y, Miura Y, Yagasaki K. Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action.Cancer Lett 2001;167:151-6. Hascalik S, Celik O, Turkoz Y, et al. Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. J Clin Oncol 2001;19:2739-45. 
Medicine & Science in Sports & Exercise 2011;43(5). View abstract. Mol.Pharmacol. View abstract. resveratrol Vaz-da-Silva, M., Loureiro, A. I., Falcao, A., Nunes, T., Rocha, J. F., Fernandes-Lopes, C., Soares, E., Wright, L., Almeida, L., and Soares-da-Silva, P. Effect of food on the pharmacokinetic profile of trans-resveratrol. Seely, K. A. Cannabinoid receptor inverse agonists as novel therapeutic agents." View abstract. Hector, K. L., Lagisz, M., and Nakagawa, S. The effect of resveratrol on longevity across species: a meta-analysis. Crowell JA, Korytko PJ, Morrissey RL, Booth TD, Levine BS. Chow, H. H., Garland, L. L., Hsu, C. H., Vining, D. R., Chew, W. M., Miller, J. Nutr Res 2001;21:747-53. 
Biochem.Pharmacol. 
1979;18:244-253. J Alzheimers.Dis 2010;19(4):1101-1122. View abstract. Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. View abstract. Levenson, A. S., Gehm, B. D., Pearce, S. T., Horiguchi, J., Simons, L. A., Ward, J. E., III, Jameson, J. L., and Jordan, V. C. Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha. Docherty JJ, Fu MM, Stiffler BS, et al. resveratrol supplements 
View abstract. Clin Sci (Lond) 2000;98(5):537-543. View abstract. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. resveratrol finest softgels nutrition mg each strength count extra pack Chang, T. K., Chen, J., and Lee, W. B. 
Yu, H. P., Hsu, J. C., Hwang, T. L., Yen, C. H., and Lau, Y. T. Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway. Antiplatelet activity of cis-resveratrol. 2001;37(3):262-270. View abstract. Higher doses of up to 3000 mg have been taken by mouth safely for up to 8 weeks. Resveratrol does not benefit patients with nonalcoholic fatty liver disease. lifeirl Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. Oat consumption does not affect resting casual and ambulatory 24-h arterial blood pressure in men with high-normal blood pressure to stage I hypertension. 
View abstract. Lee, J. E. and Safe, S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Liang, Y. C., Tsai, S. H., Chen, L., Lin-Shiau, S. Y., and Lin, J. K. Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. View abstract. Yu, H. P., Hwang, T. L., Hwang, T. L., Yen, C. H., and Lau, Y. T. Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway. 7-18-2003;73(9):1199-1213. Spine (Phila Pa 1976.) Resveratrol in health and disease. Nicolini, G., Rigolio, R., Miloso, M., Bertelli, A. If you have any condition that might be made worse by exposure to estrogen, don"t use resveratrol. 10-1-2011;36(21):E1373-E1384. View abstract. View abstract. View abstract. 500mg resveratrol View abstract. Pregliasco, F. and Cogo, R. [Antioxidant and immunomodulating compounds in older people undergoing seasonal influenza vaccination improve serological response and reduce tract respiratory episodes] L'uso di sostanze antiossidanti ed immunomodulanti in una popolazione anziana so. Cancer Res. resveratrol aging A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., Jamieson, H. A., Zhang, Y., Dunn, S. R., Sharma, K., Pleshko, N., Woollett, L. A., Csiszar, A., Ikeno, Y., Le Couteur, D., Elliott, P. J., Becker, K. G., Navas, P., Ingram, D. K., Wolf, N. S., Ungvari, Z., Sinclair, D. A., and de Cabo, R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Some people apply resveratrol to their skin to treat acne. Martin AR, Villegas I, La Casa C, de la Lastra CA. View abstract. View abstract. View abstract. vitamins, herbs, dietary supplements a-z list. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Pancreas 2009;38(8):947-953. Gehm BD, McAndrews JM, Chien PY, Jameson JL. 
View abstract. 2012;32(7):537-541. Some medications changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others. Neurosci Lett 2003;351:83-6. Martinez, J. and Moreno, J. J. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Arterioscler.Thromb.Vasc.Biol 1999;19(2):419-426. Cancer Res 2004;64:1452-9. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.
2010;49(7):449-454. Neurosci.Lett. 2012;67(12):1307-1312. Bertelli AA, Giovannini L, Bernini W, et al. Daffner, K. R. Promoting successful cognitive aging: a comprehensive review.
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